A New Solution for Physiological Stress, Occasional Pain & Discomfort
It isn’t unusual to feel physiological stress, discomfort or stiffness when going about your life. In fact, during these challenging times, everyday stress is at an all-time high, and there is no doubt that it has a tremendous impact on your health.
A novel ingredient to support physiological stress is palmitoylethanolamide (PEA). While traditionally sourced using harsh solvents and synthetic methods, Enzyme Science pioneered a natural extract of this ingredient, sourced from safflower lecithin. This product, (PEA)+ only utilizes naturally-derived palmitoylethanolamide from safflower seed. In combination with Meriva® Curcumin, this formula provides natural support for the entire body with a focus on the body’s nervous, immune, and muscular systems.*
Palmitoylethanolamide (PEA) is an extensively researched natural ingredient for important neuroprotective actions.*1 This ingredient has been utilized for decades and is available in dietary supplements worldwide as an option for the onset of physiological stress.*
When excited nerves issue sensory information to the brain, the body can react in the form of uncomfortable sensations. For those experiencing only occasional discomforts, a natural approach may be the best option to alleviate physical suffering.*
PEA is an endogenous fatty acid amide that belongs to the family of biologically active lipids that are increased by the body to soothe discomfort naturally.*3
The biological properties and mechanisms of PEA naturally produced by the body, involve a variety of effects including those upon glial and mast cells, cannabinoid-2 receptors, NF-kB, and effects on the nuclear receptor peroxisome proliferator‐activated receptors (PPARs).4
Glial and mast cells naturally play a key role in the body’s management of discomfort. Cannabinoid-2 receptors are more often found on immune cells, in the gastrointestinal tract, and in the peripheral nervous system. In addition, PEA enhances the effects of the fatty acid anandamide (also referred to as the “bliss molecule”) when it binds to CB receptors.*
In optimal health, the body’s natural production of PEA is in homeostasis. This balance can sometimes be compromised due to negative stimuli. As a result, the response to this threat of imbalance can cause a deficiency in PEA production. Supplementation of PEA works with the body to support this delicate balance, calm discomfort, and promote levels for wellbeing.* In combination with curcumin, these supplements provide natural support for the entire body with a focus on the body’s nervous, immune, and muscular systems.*
1.Scuderi C, Bronzuoli MR, Facchinetti R, et al. Transl
Psychiatry. 2018 Jan 31;8(1):32. doi: 10.1038/s41398-017-0076-4.
2.Sansgiry SS, Bhansali AH, Bapat SS, Xu Q. Integr Pharm
Res Pract. 2016 Dec 19;6:1-6. doi:10.2147/IPRP.S103494. eCollection 2017.
Review.
3.Gabrielsson L, Mattsson S, Fowler CJ. Br J Clin
Pharmacol. 2016;82(4):932-42.
4.Petrosino S, Di Marzo V. Br J Pharmacol. 2017
Jun;174(11):1349-1365. doi: 10.1111/bph.13580. Epub 2016 Sep 29. Review.