For thousands of years, mushrooms have been used to support whole-body health.[1] They are full of protein, fiber, B vitamins, vitamin D, antioxidants, potassium, selenium and phytonutrients.[2] Not only is their meaty umami flavor desired in the culinary world, mushrooms are also gaining rapid interest for their health benefits, specifically immune-promoting benefits. [3] We now understand that the power of mushrooms begins with beta-glucans.
What are beta-glucans?
Much of the immune focused research leads to beta-glucans as the major beneficial bioactive component.[3] Beta-glucans are polysaccharides found in seaweed, baker’s yeast, oats, and of course, mushrooms. The structure of beta-glucans, which will vary based on the source, determines biological activity. Beta-glucans sourced from baker’s yeast and mushrooms are more specifically known for supporting immune health.[4]
How do beta-glucans work?
Beta-glucans support the growth and activity of the intestinal microbiota by acting as a prebiotic.[4] Healthy gut microbiota are a critical aspect of optimal immune health—but that’s not the only way beta-glucans support health. When ingested, beta-glucans interact with receptors, such as complement receptor 3, dectin-1, and Toll-like receptor 2, present on immune cells like macrophages and dendritic cells.[4] The beta-glucans help macrophage activity and the overall immune response is faster and more robust.[4]
The immune power of mushrooms was highlighted in a clinical study published in the Journal of the American College of Nutrition. Fifty-two healthy subjects were given 5 or 10 g of dried mushrooms per day. Compared to baseline, after 4 weeks, there was an increase in T-cells, natural killer (NK) cells, salivary IgA, cytokines that promote a healthy inflammatory response (IL-4 and IL-10), and a roughly 30% decrease in C-reactive protein.[5]
Life Extension’s Commitment to Immune Support
For decades, Life Extension® has written about the beneficial properties of mushrooms. In 2012, they developed, a full-spectrum standardized extract that encourages the function of hematopoietic stem cells, T cells, and the production of superoxide dismutase (SOD), catalase and glutathione.*
The latest addition to the mushroom category is built around the large body of research revealing that three specific mushrooms, shiitake, maitake, and chaga, support immune function. These mushrooms are combined with a patented beta-glucan from baker’s yeast in. This formula is gluten-free, vegetarian, and non-GMO. Available in an easy-to-swallow capsule, this formula provides the equivalent of approximately one and a half servings of fresh mushrooms to support a healthy immune response.*