Indication Targeted Probiotics: Immunity

simple steps for identifying quality and efficacy

The wide reaching influence of the gut microbiome as a research topic is one of endless fascination. Although the majority of integrative practitioners include probiotics as a routinely recommended supplement for microbiome health and diversity, Nutrition Business
Journal describes a growing interest in probiotics for immune support.[1] This comes as no surprise considering the clear association between gut microbes, the gut associated lymphoid tissue (GALT), and immune function.

Not all probiotic strains are optimally equipped for effective immune support however. To help narrow the field, to follow are a few simple guidelines to identify the best suited probiotic formulations for targeted indications with specific focus on immunity.

1. Laboratory validated strain significance:

Akin to the differences among dog breeds, mechanistic strengths among various strains within the same probiotic species can vary quite significantly. When targeting immune function, it is important to verify relevant functional properties including inhibition of
pathogenic bacteria, toxin degradation, defensin and anti-inflammatory cytokine production. Verified via in vitro techniques and preclinical studies, this data allows the manufacturer to confidently formulate an indication-suitable blend. Brands committed to this level of stringent strain selection are generally very pleased to share their findings.

2. Formulation synergy and performance:

Based on the strain significance data generated, the formulator can now create a balanced blend for a specific indication such as immune support. Although evidence based, the performance of individual strains alone is not sufficient to determine likely outcomes. It turns out that various probiotic strains can be enhanced by, or diminished by, other strains and components in the final formulation. Based on this understanding, it is crucial to test the performance of the specific commercial blend in human trials. Tempting as it may be, relying on individual strain studies to assess the efficacy of a unique formulation is an unreliable and potentially misleading approach. Trials are complex and expensive, but brands that invest in this level of quality assurance provide clinicians with real insights into formulation performance and clinical efficacy.

3. Strain survival and activity:

The final critical component of a high performance probiotic lies in its ability to arrive at its intended destination alive and active. There are several approaches to addressing gastric survival, but proof of concept is far more important than the selected technique. QA quality process will include gastric tolerance and metabolic activity assessment through intestinal simulation studies at time of manufacture as well as throughout the stated shelf life. Brands that embrace this commitment assure full potency throughout the stated expiration and will gladly share that data with interested practitioners.

There’s no shortage of probiotic supplements on the market, but they are not all created equal. And targeted-indication formulations can be among the most challenging to effectively formulate. Opting for a proven line from a manufacturer committed to the highest quality standards is the best way to ensure positive outcomes. Ask questions. Demand data. Generate your own case studies. You and your patients deserve it.

[1] NBJ Supplement Business Journal Report 2020. New Hope Media.