OAT Study Review – The Effect of Botanicals on Arabinose
Bio-Botanical Research / Biocidin® practices collaboration with other
authorities and organizations in the industry. It elevates all of us and brings
credibility to the field of Functional and Integrative Medicine – broadening
our reach and our ability to make a difference. Power with rather than power
over.
Some of the most challenging cases we see in
clinical practice are patients who carry a constellation of vague yet
debilitating symptoms. Headache, fatigue, mood fluctuations, pain, sleep
issues, brain fog – all commonly seen in clinical practice – are some of the
trickiest conditions for identifying a clear therapeutic direction.
Often, our foundational tools of addressing
diet, exercise, sleep, and stress result in significant improvement. But
sometimes patients plateau or do not respond. Chronic overgrowth of
microorganisms, including Candida, can be a contributing factor. Assessing and
addressing microbial balance can bring your patients to a whole new level of
well-being.
Bio-Botanical Research / Biocidin® recently
completed a study in partnership with Great Plains Laboratory. We evaluated the
effect of three products on markers commonly associated with complex illness by
measuring organic acids (OAT). Dr. Kurt Woeller, an expert on OAT
interpretation, assisted us with data analysis.
Inclusion criteria: All participants had a moderate- to
high-symptom score on a numerical scale assessing symptoms (pain, brain fog,
allergy, and/or fatigue). Participants could not be taking antimicrobials or
probiotics.
Protocol: For eight weeks, participants were given:
One biocidal botanical combination containing Bilberry extract, Noni extract,
Milk Thistle, Echinacea Purpurea extract, Echinacea Angustifolia, Goldenseal,
Shiitake extract, White Willow Bark, Garlic, Grape Seed extract, Black Walnut
(hull and leaf), Raspberry, Fumitory extract, Gentian, Tea Tree oil, Galbanum
oil, Lavender oil, and Oregano oil.
One botanical containing Olive (Olea Europaea) Leaf Extract (Standardized to min 18% Oleuropein), Garlic
(bulb), Goldenseal (root), Milk Thistle extract (seed), St. John’s Wort (aerial
part), Uva Ursi (leaf), American Ginseng extract (root), Bladderwrack (whole
plant), Cordyceps (Cordyceps sinensis) (mycelium) extract, Dandelion (Taraxacum
officinale) root, Noni (Morinda citrifolia) fruit extract, White Willow (Salix
alba) Bark.
One binding agent containing Zeolite clay, Activated Charcoal, Aloe Vera
(inner leaf), Silica (as Monomethylsilanetriol), Apple Pectin, Humic Acid,
Fulvic Acid.
One of the markers on the OAT is arabinose, a sugar
aldehyde. Arabinose is a marker for invasive and long-standing Candida
infection. All units were measured in mmol/mol creatinine.
- In a sample of 25 patients with elevated arabinose:
- 19 participants (76%) showed improvement,
with an average drop of 20 units - 11 out of 19 participants who showed
improvement had normalization of arabinose levels - The largest shift was a change from 60 to 11
- Five participants (24%) showed no change or
an increase in arabinose, with an average increase of 16.3 mmol/mol creatinine
These results indicate that the nutritional supplementation
used in the above protocol may effect positive change in the presence of invasive
candidiasis and offer a method for supporting systemwide healthy microbial
balance.
“Overall, the single largest positive change between the
initial OAT and the follow-up was arabinose. Eleven of the 19 OATs had complete
normalization of arabinose. This marker is linked to the invasive nature of
Candida.”
– Dr. Kurt Woeller, DO